Some articles published in Haematologica in were particularly relevant. The first written by Giuseppe Pianese — who worked at the Institute of Pathological Anatomy and Histology of Naples, concluded that platelets were not stable elements of blood and did not derive from megakaryocytes, but were formed in particular conditions, just as fibrin is formed from fibrinogen.
So, since the megakaryocytes contained these corpuscles in their cytoplasm, it seemed that they produced them. In addition, platelets adhere to megakaryocytes and therefore the latter may seem to release them. The origin of the platelets was, therefore, according to Perroncito, still unknown.
A precise and determined position in favor of the theory of the origin of platelets from megakaryocytes was taken by Giovanni Di Guglielmo — from Naples in a work performed under the direction of Ferrata. In some beautiful color illustrations he showed the formation and release of platelets from megakaryocytes both through the fragmentation of their cytoplasm and via the emission of long cytoplasmic extroflexions.
In the years immediately following its foundation, Haematologica published numerous other works on the genesis of platelets. In the end, it was again Di Guglielmo who wrote the most lucid work on the origin of these corpuscles, reaffirming the correct thesis of their derivation from megakaryocytes.
The theory that megakaryocytes are present in the circulatory system not only in pathological conditions but also in healthy subjects and contribute to the formation of platelets has been definitively confirmed very recently with the documentation, in the mouse, of the release of platelets by the megakaryocytes migrated through the circulatory stream in the lung.
From the start, serology and serodiagnosis of infectious diseases have always found a place in Haematologica. Following the cytological study of Golgi, some works published in the journal dealt with speculative and sometime bizarre hypotheses about the structure and shape of red blood cells.
However, the nature of megakaryocytes and their role in the production of platelets continued to be at the center of interest. Other authors thought that megakaryocytes derived from the fusion of several cells.
This was one of the most important topics of study at the Medical Clinic of Pavia. In the mids, immediately following the arrival of Ferrata as director and of his assistant Di Guglielmo, the Clinic had immediately become the most important center of hematology in the whole of Italy. Thus, Di Guglielmo was able to argue that megakaryocytes derived from a process of cell fusion that eventually gave rise to their multi-nuclear appearance; 59 an idea shared by others.
Figure 6. Giovanni di Guglielmo. From its first volume, Haematologica continued to publish many works dedicated to the clinical practice and clinical pathology of hematologic diseases.
Of course, the founder of the journal, Ferrata, contributed works that resulted from his collaboration with members of the scientific school that was being formed around him first in Naples, and then in Siena and Pavia , in particular with his most brilliant pupil at that time, Di Guglielmo. In addition to articles on pernicious anemia, studies appeared on the histogenesis of granulocytic leukemia. Many other areas of clinical hematology and related fields of study were also touched on, including: paroxysmal hemoglobinuria, the clinical and biological significance of Bence-Jones proteinuria, the pathogenesis of Gaucher disease, studies on leukemia, investigation of the forensic applications of hematology, and so on.
Haematologica has also always provided a means of making research performed outside Italy available to a wider readership, with works published in French, German and English. Thanks to the credibility and high professional profile of the director, Ferrata, the prestige of the journal immediately attracted the publication of studies produced by illustrious European names in the medical sciences. In , Otto Lubarsch — , director of the Institute of Pathology of the University of Berlin known for defining carcinoid tumors published a paper on the pathogenesis of thrombosis and embolism.
The paper dealt with the structure and origin of lymph sinuses of mammalian lymph nodes. Many were destined to have important careers in Italian Hematology and Medical Clinic departments. Aminta Fieschi — was an active contributor to both clinical research and in cytological studies. In , Edoardo Storti — made his debut for Haematologica with a work on experimental anemia during an infection with Botriocephalus. A few years later he would become one of the main collaborators of Ferrata 96 94 and his last scientific heir.
In , Haematologica published his study on schistosomiasis anemia in Libyan patients who he had examined during a scientific expedition. Important works were published in the journal by the principal Italian hematologists of the day. In , with Europe thrown into the turmoil of the Second World War, Haematologica celebrated its twentieth anniversary with an impressive volume in honor of the founder Adolfo Ferrata, promoted by his most illustrious pupil Di Guglielmo.
Di Guglielmo undersigned the introduction, dedicated with great affection to his teacher, and was himself the author of an extensive study of the pathology of the spleen. Among the many works that came from Italy, one stood out clearly and was signed by Edoardo Storti with his collaborator Mario Brotto who had graduated just two years before.
The topic was immediately discussed in the following months, and very soon the idea of the neoplastic origin of leukemias became a fact adopted by the international community of hematologists. Table 1. Haematologica Impact Factor for the years — In the following years, the journal continued to publish significant works on many areas of blood morphology and pathology, for example, on the relationship between pulmonary tuberculosis and hematopoiesis, in splenectomy in aplastic myelosis, on a form of familial leukemia, on chronic erythremic myelosis, and others.
The number of articles was, however, drastically reduced, and there were no published contributions from foreign research centers. Ferrata died suddenly in , and the direction of Haematologica was assigned to Giovanni Di Guglielmo from to and then to Paolo Introzzi from to Precision Medicine. Genome Editing and Gene Therapy. Immunologic Treatment. Research Support and Funding. Hematology Legends Notable leaders who have been instrumental in the development of ASH and who have greatly advanced the field.
Blood and the history of the diagnoses and treatment of blood diseases are of interest to many people. This book traces the development of the interest in diseases of the blood since earliest times. Rituals associated with blood together with a belief held until relatively recently that blood contains the soul or memory is explored.
Certain figures that appear to have been airbrushed out of history are rightly reinstated. Novel developments since the s are documented, including changes in diagnostic technologies and the genetic revolution.
The new era in haematology, as in other branches of medicine, will undoubtedly bring challenges as well as benefits. The relationships between doctors and their patients are undergoing profound changes, and the final results of that change may throw up more problems than solutions.
The relentless increase in bureaucracy and the takeover by modern management techniques is critically evaluated. Shaun R.
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